Alzheimer's disease is characterized by plaques of amyloid-beta peptide, cleaved from amyloid-beta protein precursor . Our hypothesis is that lifespan profiles of AD-associated mRNA and protein levels in monkeys would differ from mice and that differential lifespan expression profiles would be useful to understand human AD pathogenesis. We compared profiles of AbetaPP mRNA, AbetaPP protein, and Abeta levels in rodents and primates. We also tracked a transcriptional regulator of the AbetaPP gene, specificity protein 1 , and the beta amyloid precursor (...) cleaving enzyme . In mice, AbetaPP and SP1 mRNA and their protein products were elevated late in life; Abeta levels declined in old age. In monkeys, SP1, AbetaPP, and BACE1 mRNA declined in old age, while protein products and Abeta levels rose. Proteolytic processing in both species did not match production of Abeta. In primates, AbetaPP and SP1 mRNA levels coordinate, but an inverse relationship exists with corresponding protein products as well as Abeta levels. Comparison of human DNA and mRNA sequences to monkey and mouse counterparts revealed structural features that may explain differences in transcriptional and translational processing. These findings are important for selecting appropriate models for AD and other age-related diseases. (shrink)

The sporadic nature of Alzheimer's disease argues for an environmental link that may drive AD pathogenesis; however, the triggering factors and the period of their action are unknown. Recent studies in rodents have shown that exposure to lead during brain development predetermined the expression and regulation of the amyloid precursor protein and its amyloidogenic beta-amyloid product in old age. Here, we report that the expression of AD-related genes [APP, BACE1 ] as well as their transcriptional regulator were elevated in aged (...) monkeys exposed to Pb as infants. Furthermore, developmental exposure to Pb altered the levels, characteristics, and intracellular distribution of Abeta staining and amyloid plaques in the frontal association cortex. These latent effects were accompanied by a decrease in DNA methyltransferase activity and higher levels of oxidative damage to DNA, indicating that epigenetic imprinting in early life influenced the expression of AD-related genes and promoted DNA damage and pathogenesis. These data suggest that AD pathogenesis is influenced by early life exposures and argue for both an environmental trigger and a developmental origin of AD. (shrink)

Alzheimer's disease is characterized by amyloid-beta peptide -loaded plaques in the brain. Abeta is a cleavage fragment of amyloid-beta protein precursor and over production of APP may lead to amyloidogenesis. The regulatory region of the APP gene contains consensus sites recognized by the transcription factor, specificity protein 1 , which has been shown to be required for the regulation of APP and Abeta. To understand the role of SP1 in APP biogenesis, herein we have characterized the relative distribution and localization (...) of SP1, APP, and Abeta in various brain regions of rodent and primate models using immunohistochemistry. We observed that overall distribution and cellular localization of SP1, APP, and Abeta are similar and neuronal in origin. Their distribution is abundant in various layers of neocortex, but restricted to the Purkinje cell layer of the cerebellum, and the pyramidal cell layer of hippocampus. These findings suggest that overproduction of Abeta in vivo may be associated with transcriptional pathways involving SP1 and the APP gene. (shrink)

A total of 944 expressed sequence tags generated 2212 EST loci mapped to homoeologous group 1 chromosomes in hexaploid wheat. EST deletion maps and the consensus map of group 1 chromosomes were constructed to show EST distribution. EST loci were unevenly distributed among chromosomes 1A, 1B, and ID with 660, 826, and 726, respectively. The number of EST loci was greater on the long arms than on the short arms for all three chromosomes. The distribution of ESTs along chromosome arms (...) was nonrandom with EST clusters occurring in the distal regions of short arms and middle regions of long arms. Duplications of group 1 ESTs in other homoeologous groups occurred at a rate of 35.5%. Seventy-five percent of wheat chromosome 1 ESTs had significant matches with rice sequences, where large regions of conservation occurred between wheat consensus chromosome 1 and rice chromosome 5 and between the proximal portion of the long arm of wheat consensus chromosome 1 and rice chromosome 10. Only 9.5% of group 1 ESTs showed significant matches to Arabidopsis genome sequences. The results presented are useful for gene mapping and evolutionary and comparative genomics of grasses. (shrink)

The focus of this study was to analyze the content, distribution, and comparative genome relationships of 996 chromosome bin-mapped expressed sequence tags accounting for 2266 restriction fragments on the homoeologous group 3 chromosomes of hexaploid wheat. Of these loci, 634, 884, and 748 were mapped on chromosomes 3A, 3B, and 3D, respectively. The individual chromosome bin maps revealed bins with a high density of mapped ESTs in the distal region and bins of low density in the proximal region of the (...) chromosome arms, with the exception of 3DS and 3DL. These distributions were more localized on the higher-resolution group 3 consensus map with intermediate regions of high-mapped-EST density on both chromosome arms. Gene ontology classification of mapped ESTs was not significantly different for homoeologous group 3 chromosomes compared to the other groups. A combined analysis of the individual bin maps using 537 of the mapped ESTs revealed rearrangements between the group 3 chromosomes. Approximately 232 of the consensus mapped ESTs matched sequences on rice chromosome 1 and revealed large- and small-scale differences in gene order. Of the group 3 mapped EST unigenes ∼21 and 32% matched the Arabidopsis coding regions and proteins, respectively, but no chromosome-level gene order conservation was detected. (shrink)

To localize wheat ESTs on chromosomes, 882 homoeologous group 6-specific ESTs were identified by physically mapping 7965 singletons from 37 cDNA libraries on 146 chromosome, arm, and sub-arm aneuploid and deletion stocks. The 882 ESTs were physically mapped to 25 regions flanked by 23 deletion breakpoints. Of the 5154 restriction fragments detected by 882 ESTs, 2043 were localized to group 6 chromosomes and 806 were mapped on other chromosome groups. The number of loci mapped was greatest on chromosome 6B and (...) least on 6D. The 264 ESTs that detected orthologous loci on all three homoeologs using one restriction enzyme were used to construct a consensus physical map. The physical distribution of ESTs was uneven on chromosomes with a tendency toward higher densities in the distal halves of chromosome arms. About 43% of the wheat group 6 ESTs identified rice homologs upon comparisons of genome sequences. Fifty-eight percent of these ESTs were present on rice chromosome 2 and the remaining were on other rice chromosomes. Even within the group 6 bins, rice chromosomal blocks identified by 1-6 wheat ESTs were homologous to up to 11 rice chromosomes. These rice-block contigs were used to resolve the order of wheat ESTs within each bin. (shrink)

The complex hexaploid wheat genome offers many challenges for genomics research. Expressed sequence tags facilitate the analysis of gene-coding regions and provide a rich source of molecular markers for mapping and comparison with model organisms. The objectives of this study were to construct a high-density EST chromosome bin map of wheat homoeologous group 2 chromosomes to determine the distribution of ESTs, construct a consensus map of group 2 ESTs, investigate synteny, examine patterns of duplication, and assess the colinearity with (...) class='Hi'>rice of ESTs assigned to the group 2 consensus bin map. A total of 2600 loci generated from 1110 ESTs were mapped to group 2 chromosomes by Southern hybridization onto wheat aneuploid chromosome and deletion stocks. A consensus map was constructed of 552 ESTs mapping to more than one group 2 chromosome. Regions of high gene density in distal bins and low gene density in proximal bins were found. Two interstitial gene-rich islands flanked by relatively gene-poor regions on both the short and long arms and having good synteny with rice were discovered. The map locations of two ESTs indicated the possible presence of a small pericentric inversion on chromosome 2B. Wheat chromosome group 2 was shown to share syntenous blocks with rice chromosomes 4 and 7. (shrink)

A total of 1918 loci, detected by the hybridization of 938 expressed sequence tag unigenes from 26 Triticeae cDNA libraries, were mapped to wheat homoeologous group 4 chromosomes using a set of deletion, ditelosomic, and nulli-tetrasomic lines. The 1918 EST loci were not distributed uniformly among the three group 4 chromosomes; 41, 28, and 31% mapped to chromosomes 4A, 4B, and 4D, respectively. This pattern is in contrast to the cumulative results of EST mapping in all homoeologous groups, as reported (...) elsewhere, that found the highest proportion of loci mapped to the B genome. Sixty-five percent of these 1918 loci mapped to the long arms of homoeologous group 4 chromosomes, while 35% mapped to the short arms. The distal regions of chromosome arms showed higher numbers of loci than the proximal regions, with the exception of 4DL. This study confirmed the complex structure of chromosome 4A that contains two reciprocal translocations and two inversions, previously identified. An additional inversion in the centromeric region of 4A was revealed. A consensus map for homoeologous group 4 was developed from 119 ESTs unique to group 4. Forty-nine percent of these ESTs were found to be homoologous to sequences on rice chromosome 3, 12% had matches with sequences on other rice chromosomes, and 39% had no matches with rice sequences at all. Limited homology was found between wheat ESTs on homoeologous group 4 and the Arabidopsis genome. Forty-two percent of the homoeologous group 4 ESTs could be classified into functional categories on the basis of blastX searches against all protein databases. (shrink)

The objectives of this study were to develop a high-density chromosome bin map of homoeologous group 7 in hexaploid wheat, to identify gene distribution in these chromosomes, and to perform comparative studies of wheat with rice and barley. We mapped 2148 loci from 919 EST clones onto group 7 chromosomes of wheat. In the majority of cases the numbers of loci were significantly lower in the centromeric regions and tended to increase in the distal regions. The level of duplicated (...) loci in this group was 24% with most of these loci being localized toward the distal regions. One hundred nineteen EST probes that hybridized to three fragments and mapped to the three group 7 chromosomes were designated landmark probes and were used to construct a consensus homoeologous group 7 map. An additional 49 probes that mapped to 7AS, 7DS, and the ancestral translocated segment involving 7BS also were designated landmarks. Landmark probe orders and comparative maps of wheat, rice, and barley were produced on the basis of corresponding rice BAC/PAC and genetic markers that mapped on chromosomes 6 and 8 of rice. Identification of landmark ESTs and development of consensus maps may provide a framework of conserved coding regions predating the evolution of wheat genomes. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:François H. Lapointe PHILOSOPHY AND LITERATURE: A BIBLIOGRAPHIC SURVEY ThL· survey is limited to articles written in English that have appeared in journals published between 1 January 1974 and 31 December 1976. Abbott, Don. "Marxist Influences on the Rhetorical Theory of Kenneth Burke." Philosophy and Rhetoric 7 (1974): 217-33. Abel, Lionel. "Jacques Derrida: His 'Difference' With Metaphysics." Salmagundi no. 25 (1974): 3-21. Adamowski, T. H. "Character and Consciousness: D. (...) H. Lawrence, Wilhelm Reich, and Jean-Paul Sartre." University of Toronto Quarterly 43 (1974): 31 1-34. Adams, D. J. "Style and Social Ideas in Jacques le fataliste." Studies in Voltaire & the Eighteenth Century 124 (1974): 231-48. Adams, Hazard. "Contemporary Ideas of Literature: Terrible Beauty or Rough Beast?" Contemporary Literature 17 (1976): 349-77. Adorno, Theodor W. "Lyric Poetry and Society." Telos no. 20 (1974): 56-71. Ages, Arnold. "Bonald and the Jews." Revue de l'Université d'Ottawa 44 (1974): 32-43. Allen, Diogenes. "The Experience of Existence: Jean-Paul Sartre and Iris Murdoch." International Philosophical Quarterly 14 (1974): 181-87. Allen, Marcus. "Character Development in the Oreste of Voltaire and Les Mouches of Jean-Paul Sartre." CLA Journal 18 (1974): 1-21. Alter, Jean. "A (Terrorist) System of the Novel." Diacritics 6 (1976): 10-15. Altieri, Charles. "Wittgenstein on Consciousness and Language: A Challenge to Derridean Literary Theory." MLN 91 (1976): 1397-1423. Altieri,Charles. "Wordsworth's 'Preface' as Literary Theory." Criticism 18 (1976): 122-146. [On Wordworth and Wittgenstein.] Ames, Van Meter. "Art for Art's Sake Again?" Journal of Aesthetics and Art Criticism 33 (1975): 303-307. Appleman, Philip. "The Dread Factor: Eliot, Tennyson, and the Shaping of Science." Columbia Forum, N. S. 3 (1974): 32-38. Armstrong, Paul B. " E. M. Forster's Howard's End: The Existential Crisis of the Liberal Imagination." Mosaic 8 (1974): 183-99. Arnold, A. James. "La Condition humaine as Nietzschean Tragedy." Mélanges Malraux Miscellany 6 (1974): 15-24. 366 François H. Lapointe367 Aronson, Ronald. "L'Idiot de la famille: The Ultimate Sartre?" Telos no. 20 (1974): 90-107. Arthos, John. "Du Bartas, Petrarch and the Poetry of Deism." Rice University Studies 60 (1974): 1-17. Artz, Johannes. "Newman as Philosopher." International Philosophical Quarterly 16 (1976): 263-88. Ausmus, Harry J. "Schopenhauer's Philosophy of Language." The Midwest Quarterly 18 (1977): 169-86. Ayala, Francisco. "Ortega y Gasset, Literary Critic." Critical Inquiry 1 (1974): 395-414. Bakalar, H. Nicholas. "The Cartesian Legacy to the Eighteenth-century Grammarians." MLN 91 (1976): 698-721. Barnes, Hazel. "Apotheosis and Deification in Plato, Nietzsche and Huxley." Philosophy and Literature 1 (1976): 3-24. Baron, Dennis E. "Role Structure and the Language of Literature." Journal of Literary Semantics 4 (1975): 43-52. Barooskian, Vahan D. "The Aesthetics of the Russian Revolutionary Theatre 1917-1921." British Journal of Aesthetics 15 (1975): 99-117. Bart, B. F. "Hypercreativity in Stendhal and Balzac." Nineteenth Century French Studies 3 (1974-75): 18-39. Barthes, Roland. "An Introduction to the Structural Analysis of Narrative." New Literary History 6 (1975): 237-72. Bashford, Bruce. "The Rhetorical Method in Literary Criticism." Philosophy and Rhetoric 9 (1976): 133-46. Bass, Alan. "Time and the Witch: Femininity, Metapsychology and the Temporality of the Unconscious." MLN 91 (1976): 871-912. Bassett, Sharon. "Towards a Critique of Romanticism: Wordsworth, Pater and the 'Anima Mundi'." Criticism 17 (1975): 262-75. Batchelor, R. "Literature, Society and the Concept of Revolt." European Studies Review 5 (1975): 395-427. Battin, M. Pabst. "Aristotle's Definition of Tragedy in the Poetics, Part 1." Journal of Aesthetics and Art Criticism 33 (1974): 155-70, and Part II in Ibid. 33 (1975): 293-302. Bauer, George. "Sartre and the 'Sugars' of History." L'Esprit Créateur 15 (1975): 377-86. Baumgarten, Murray. "The Historical Novel: Some Postulates." Clio 4 (1975): 173-82. Beauchamp, Gorman. "Gulliver's Return to the Cave: Plato's Republic and Book IV of Gulliver's Travels." The Michigan Academician 7 (1974): 201-10. Bennett, Jonathan. "The Conscience of Huckleberry Finn." Philosophy 48 (1974): 123-34. Benzon, William. "Cognitive Networks and Literary Semantics." MLN 91 (1976): 952-82. Bergonzi, Bernard. "A Grid of Codes: Views of Structuralism." Encounter 45 (1975): 52-58. Berry, Wanda Warren. "The... (shrink)

A Guide to Plato's Republic provides an integral interpretation of the Republic which is accessible even to readers approaching Plato's masterwork for the first time. Written at a level understandable to undergraduates, it is ideal for students and other readers who have little or no background in philosophy or political theory. Rice anticipates their inevitable reactions to the Republic and treats them seriously, opening the way to an appreciation of the complexities of the text without oversimplifying it. While many (...) books on the Republic never stray far from explicating Plato's text, this work contrasts Plato's responses to perennial issues in philosophy and political theory with those of several key subsequent thinkers. It uses engaging examples to show the continuing relevance of Plato's arguments and introduces some basic vocabulary of philosophy and political theory, going beyond terse dictionary definitions by illustrating what technical terms mean in the context of Plato's work. The author's interpretative posture is appreciative but respectfully critical of Plato's vision. Stressing the relationship between Plato's politics and metaphysics, Rice argues that Plato's reluctance to accept the reality and consequences of finitude accounts for much of what many readers find objectionable in his politics. Lively, relatively brief, and designed to provoke discussion in the classroom, A Guide to Plato's Republic is ideal for political theory and introduction to philosophy courses as well as other courses that assign the Republic as a primary text. (shrink)

Written by five scholars whose expertise extends across the disciplines of biblical, historical, systematic, and philosophical theology, this is a careful and ...

Reform of the federal income tax system has become a perennial item on the domestic policy agenda of the United States, although there is considerable uncertainty over specifics. Indeed the recent report of the President's Advisory Panel on Federal Tax Reform recommended not one but two divergent policy directions. In Fundamental Tax Reform, top experts in tax policy discuss a wide range of issues raised by the prospect of significant tax reform, identifying the most critical questions and considering whether the (...) answers are known, unknown--or unknowable. The debates over tax reform usually concern the advantages and disadvantages of income-based taxation as opposed to any of the several alternative forms of consumption-based taxation. The book opens with chapters that discuss the strengths, weaknesses, and political feasibility of these options. Other chapters consider the effect of tax reform on businesses, especially their investment behavior, and include a discussion of possible problems in any transition to a consumption-based tax; international taxation issues arising in an era of globalization; and individual behavioral response to tax reform, including a view of the topic from the perspective of the relatively new field of behavioral economics. ContributorsRosanne Altshuler, Alan J. Auerbach, John W. Diamond, Harry Grubert, Arnold C. Harberger, Kevin A. Hassett, Thomas J. Kniesner, Laurence J. Kotlikoff, Edward J. McCaffery, Kathryn Newmark, David Rapson, Daniel Shaviro, Joel Slemrod, James P. Ziliak, George R. ZodrowDiscussants James Alm, Henry J. Aaron, Charles L. Ballard, Leonard E. Burman, Robert S. Chirinko, Robert D. Dietz, Malcolm Gillis, Roger H. Gordon, Jane G. Gravelle, Timothy S. Gunning, James M. Poterba, Thomas S. Neubig, Alan Viard, George Yin John W. Diamond is Edward and Hermena Kelly Fellow in Tax Policy and Adjunct Professor of Economics at the Baker Institute for Public Policy, Rice University. George R. Zodrow is Professor of Economics and Rice Scholar at the Baker Institute and International Research Fellow at the Centre for Business Taxation, Oxford University. (shrink)

This is the first comprehensive study of Schrödinger's scientific and philosophical writings. The task requires a person trained thoroughly in physical science and yet capable of appreciating the sometimes puzzling philosophical ideas Schrödinger put forward. Professor Scott, a physicist, is remarkably successful at communicating both the physical and the philosophical ideas. After a brief summary of Schrödinger's diverse writings, he divides the writings into four groups which are treated in separate chapters. The first group, including very early papers, deals with (...) Schrödinger's work on Statistical Mechanics, and statistical theories in general. The second covers the crucial development of Wave Mechanics. The third concerns Schrödinger's interpretation of quantum mechanics and the important departures from the prevailing views of the Copenhagen school. Finally the fourth group contains Schrödinger's views on life and the self. The author shows that Schrödinger was led to his doctrine of identity by reflecting on the paradox of freedom and determinism. His study "What is Life?" convinced him that living systems are governed by the law of causality but he also believed that men were free. The doctrine of identity was his solution to the paradox. Scott is critical of this solution and a number of other doctrines of Schrödinger. The book is clearly written throughout and is a good introduction to Schrödinger's thought.--R. H. K. (shrink)

This publication of the proceedings of the first of a new series of colloquia to be held at the University of Western Ontario contains an opening address on existence and quantification by W. V. Quine and three symposia. The paper discussed in the first of these symposia, "Descartes' Ontological Argument" by Anthony Kenny, follows closely one chapter of Kenny's recent book on Descartes. Kenny's paper contains both an interesting account of Descartes' views and some challenging remarks about ontological arguments in (...) general. His paper is discussed in separate commentaries by Norman Malcolm and Terence Penelhum. An interesting feature of this volume is that some comments from the floor are recorded and included along with the regular commentaries. Ernest Sosa and Bernard Williams comment on Kenny's paper along with Malcolm and Penelhum. Kenny responds to all four commentators. The other two symposia follow a similar format. The second, "On Events and Event-descriptions," features a paper by R. M. Martin which focuses on the logic of event descriptions and their role in scientific explanation. Events for Martin are extensional entities, unlike facts, but like facts they are "fictitious in the sense of being handled on virtually." His views are discussed by Donald Davidson, R. J. Butler and Wesley Salmon. In the third symposium on "Existence Assumptions in Practical Thinking," Stephan Körner elaborates on his view of effective choice, relating his account to those of Hume, Kant, and Peirce on the specific topic of the relationship of choice and natural necessity. The commentaries of J. J. Thomson and Bernard Williams are helpful here in getting Körner to clarify his interesting views. In sum, this first colloquium at the University of Western Ontario features genuine philosophical communication on some important issues.--R. H. K. (shrink)

This book is an introduction to certain problems in the philosophy of science through the study of four case histories in the history of science. It is designed for undergraduate science majors whom, the author feels, often have difficulties connecting the usual discussions in the philosophy of science with the science they have studied and are studying. Each case history is followed by a commentary which considers its philosophical implications. The first case, Harvey's discovery of the circulation of the blood, (...) is treated briefly and from it some implications are drawn about the relation of simple theories and the facts supporting them. The next three cases are considerably more complicated and receive more extended treatment. The first of these concerns scientific work on the motions and spacing of the planets from early Babylonian and Greek observations and theories to Kepler and Newton. The second concerns the development of the periodic table of the elements from Dalton to Mendeleev and the third discusses gene theories of inheritance from Mendel onward. In connection with these studies the author considers questions about the nature of theories and theoretical entities, methods of testing theories, the dependence of observation on theory and the issues of reduction among other topics. Although he limits his discussion to a few selected topics in the philosophy of science he has written an informative and interesting study which should fulfill its stated aims.--R. H. K. (shrink)

This book is far more than an exposition of Frege's logical system and semantic concepts, although it is that. The author puts forward the challenging thesis that in trying to cope with Russell's paradox Frege deserted principles of his system which he had relied on throughout. Sternfeld attempts to show, by offering his own interpretation of Frege's logical theory, that if Frege had relied consistently on his previously formulated logical principles, Russell's paradox would have given him no trouble. Further, he (...) uses these arguments as a basis for defending the general thesis that paradoxes and other difficulties with various logical systems can only be discussed relative to the philosophical principles underlying the logical system and adopted independently of it. While these are the most challenging of the book's theses they are not its only topics. The author seems to have read everything by and about Frege and is in control of his material. There will undoubtedly be disagreements over his interpretation of Frege because Frege did not write to make expositors happy. But all students of Frege, as well as students of the philosophy of logic and philosophy of mathematics, will find this book rewarding.--R. H. K. (shrink)

Foundations research in physics, according to Bunge, has lagged behind its sister discipline, the foundations of mathematics. His book is an attempt to partially remedy this situation by analyzing the form and content of some basic ideas in physics and presenting some of the fundamental theories of physics in an axiomatic fashion. The heart of the book consists of axiomatizations of Classical Mechanics, Classical Field Theories, and Quantum Mechanics. Bunge does not claim to be working without predecessors. While the idea (...) of a separate discipline in the foundations of physics is rather new, the existence of material that clearly belongs to foundations research is not. This is attested to by the substantial bibliography at the end of the book. But he is ideally suited to the task of bringing this difficult material together and welding it in his own fashion into a coherent whole. His grasp of physical theory is wide-ranging and he writes with clarity and wit. In the first chapter he states his views on a number of issues in the philosophy of science: explanation, prediction, operationalism, laws, and other topics. The arguments are usually summarized very briefly, or reference is made to other books. Thus those who disagree with his philosophical presuppositions will not be convinced; but friends or foes will miss a great deal of informative material if they do not push on to the axiomatizations which follow and which are the main concern of the book. This book will undoubtedly be a source-book for future foundations research in the physical sciences.--R. H. K. (shrink)

As Max Jammer has rightly said, contemporary discussion of the metrical properties of space have been dominated in recent years by the work of Adolf Grünbaum. One of Grünbaum's most important essays in this area, "Geometry, Chronometry and Empiricism" is reprinted in its entirety as the first chapter of this work. The third and final chapter is a lengthy reply to Hilary Putnam who published a critique of Grünbaum's original essay in 1963. Putnam's criticisms have not led Grünbaum to substantially (...) change his views but they have provided the means for some clarification and extension of those views, e.g., with respect to the notions of congruence and conventionality and in relation to Zeno's paradoxes, color attributes, and other topics. Between the original essay and the lengthy reply to Putnam there is a shorter chapter which deals with, among other things, the hypothesis that everything has doubled overnight, a related topic to which Grünbaum has given some attention in journal articles. It is safe to say that persons concerned with the problem of conventionalism and other philosophical problems about space will have to work their way through this important book.--R. H. K. (shrink)

Peter Geach brings the same careful attention to logical detail to these studies in the philosophy of religion and philosophy of mind as he has brought to other philosophical works. Some of the topics discussed here, however, will surprise some readers of Geach's earlier works, e.g., reincarnation, immortality, creation, praying for things to happen, and worshipping the right God. There are separate chapters on these topics as well as chapters on thought, form and existence, and the moral law. It should (...) be noted for readers who may not share Geach's interest in some of these topics that each of the chapters makes important points about issues which go beyond the topics of immediate interest. For example, Geach's two chapters on reincarnation and immortality are very interesting commentaries on the problem of personal identity, and the chapter on praying for things to happen is an interesting essay on time. The chapters on existence and thought pick up themes from Geach's earlier writing on Aquinas and Frege and mental acts. The Aristotelian roots of Geach's thought are clear in these essays from his account of existence and thought to his denial of clear sense to the idea of an immortality of a separate soul or its reincarnation. There is a helpful analytical index.--R. H. K. (shrink)

Leibniz' General Investigations, a group of memoranda on logical and methodological matters, remained unpublished until Couturat published the original Latin manuscript in 1903. Only after 1960 was a German translation made by F. Schmidt and an English translation by G. H. R. Parkinson. The present translation provides extensive reference notes to Leibniz' other manuscripts, and a commentary and notes to the text. In these respects it has some advantages over previous translations. The translation is clear although the work itself is (...) sometimes difficult to follow and the notes are most welcome. An introduction discusses the place of the General Investigations within the context of Leibniz' thought. With the interest in Leibniz' logical writings very strong at present, this new translation and commentary is most welcome.--R. H. K. (shrink)

This is a translation of Jacob Klein's study "Die Griechische Logistik und die Entstehung der Algebra" which appeared in 1934-1936. His principal thesis is that the Renaissance mathematicians of the sixteenth century did not simply continue the work of the Greek and Arab mathematicians but in the process of developing ancient mathematics introduced a radically new conception of number which has since guided modern mathematical thought. The central figure in this revolution is Vieta. Klein traces the influence of Vieta's ideas (...) upon Stevin, Descartes, Wallis, and other figures of the scientific revolution, after discussing the conception of number and arithmetic in Plato, Aristotle, and other Greek sources. Persons reading this book with a primary interest in the philosophical ideas involved will be frustrated by the mass of historical detail which often obscures rather than illuminates the philosophical issues. But the book deserves its reputation as an important historical study.--R. H. K. (shrink)

The first of these two volumes is a second edition of the first part of Jonas' comprehensive scholarly study of Gnosticism, first published in 1934. Except for minor corrections the first edition has been left unrevised. The second volume carries the study up to the third century A.D. A final volume completing the second part is promised for the near future.--R. H.

Bernard Nieuwentijt ist in der Mathematikgeschichte bekannt als Kritiker der Leibnizschen Differentialrechnung. Im Gegensatz zu dem, was häufig angenommen wird, war die Kritik an Leibniz' Methode kein Hauptanliegen Nieuwentijts. Das Ziel seines bedeutendsten mathematischen Werks, Analysis infinitorum , war die Systematisierung und logische Deduzierung der ihm bekannten Infinitesimalmethoden, besonders derer von den Engländern wie Barrow, Wallis u. a. Das Werk Leibnizens war ihm anfangs völlig unbekannt. In dem System, das Nieuwentijt selbständig entwarf, rechnete er nicht mit Infinitesimalen höheren Grades: ihre (...) Existenz hielt er für unmöglich. Dies brachte ihn zur Kritik der Leibnizschen Methode, als er später auf dessen Werk stieß. Später aber erkannte er die Unhaltbarkeit seiner Kritik, wie klar wird aus seinem posthumen Werk Gronden van zekerheid . Der Aufsatz gibt überdies zur Fundierung dieser Thesen einen sehr kurzen Überblick über Nieuwentijts mathematische Arbeiten und eine Besprechung neuerer Interpretationen. (shrink)

The experience of newborn screening for Krabbe disease in New York State demonstrates the ethical problems that arise when screening programs are expanded in the absence of true understanding of the diseases involved. In its 5 years of testing and millions of dollars in costs, there have been very few benefits, and the testing has uncovered potential cases of late-onset disease that raise difficult ethical questions in their own right. For these reasons, we argue that Krabbe screening should only be (...) continued as a research project that includes the informed consent of parents to the testing. (shrink)